We report a case of primary cutaneous infection by the emerging fungus Aspergillus ustus in an immunosuppressed patient after a domestic accident. Aspergillus ustus is a mold that rarely infects humans; only 15 systemic cases have been reported. We report the first outbreak of invasive infection caused by A . Med Mycol. Jun;45(4) Clustering of invasive Aspergillus ustus eye infections in a tertiary care hospital: a molecular epidemiologic study of an.
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The results of molecular analyses suggest genetic similarity of isolates recovered from patients.
Aspergillus ustus | Aspergillus & Aspergillosis Website
J Am Chem Soc. One patient patient 3 did not have a viable isolate stored, and 1 patient patient 5 had 3 isolates recovered during the course of infection. No changes in laboratory processing or mold identification methods occurred during the study. Results Outbreak Cases We identified 2 clusters of Axpergillus.
We report here the first aspergilluz of Aspergillus ustus endophthalmitis cases which occurred in a large tertiary care hospital during the period October to June Common source acquisition may not be precluded by case isolate separation in time as Aspergillus conidia are resistant to harsh conditions, surviving in the environment for many years in dormant phase However, the environmental niche of this fungus is not known.
In-vitro testing of susceptibility to amphotericin B is a reliable predictor of clinical outcome in invasive aspergillosis. Possible emission of a yellowish pigment. Recognition of time-clustered cases in prompted us aspergllus do this retrospective study and epidemiologic investigation.
Molecular typing of Aspergillus ustus isolates by using random amplification of polymorphic DNA. Microscopically, the conidia are large 3.
Aspergillus ustus, antifungal drug resistance, emerging pathogen, outbreak, transplantation, research. Of note, construction of a new surgery pavilion occurred outside our hospital building beginning in July and ending in December Rheumatic heart disease, prosthetic valve replacement.
Its growth on edition paper asperbillus less fast and is very weak on cotton fabric. Spot map illustrating case-patient location on the northwestern wing of the eighth floor 8NE and the seventh floor 7NE from the left panel and outbreaks right panel at the time of case diagnosis. Clinical isolates exhibited decreased susceptibility to antifungal drugs, especially azoles.
Aspergillus ustus is a microfungus and member of the division Ascomycota. Introduction to Food and Airborne Fungi.
The spot map and time line showed that cases clustered mainly along 2 corridors on 2 floors, 1 directly above the other, around the time of diagnosis. Infections caused by A. A combination of factors, including aspergilluw of underlying host immunosuppression and common source acquisition, likely played a role in the reported outbreaks.
Aspergillus ustus has been found on the surfaces of walls of caves and in indoor air of buildings  including hospitals,   soils and bat dung. Sterigmatocystis usta Bainier Aspergillus minutus Abbott Aspergillus ustus var. Support Center Support Center. On Czapek growth medium pH 5. In other projects Wikimedia Commons. In the and outbreaks, all case-patients resided in the same or adjacent rooms before diagnosis Figure 1.
In this cohort, several patients who received the combination regimen of voriconazole and caspofungin had A.
We thank Estella Whimbey and Nancy Whittington for their help with acquiring information on hospital airflow and construction activity, Robin Olsen for performing the environmental air sampling, Chris Davis for database support, David Madtes and Pat McDowell for obtaining bronchoscopic information, and S.
Abstract Aspergillus ustus is a mold that rarely infects humans; only 15 systemic cases have been reported.
The most common clinical presentations of A. Ustic acid has since been shown to occur in other fungi, notably closely related Aspergilli such as A. We report the first outbreak of invasive infection caused ustsu A. Information on timing of construction activities and airflow information was obtained from hospital engineering and infection control personnel.